The QuickScreen™ One-Step Rapid Benzodiazepines Test is a rapid, visual,
qualitative, competitive binding immunoassay for the detection of
Benzodiazepines and Benzodiazepine metabolites in human urine. The test provides
a fast confirmation of the presence of Benzodiazepines in the
subject sample at a minimum cutoff sensitivity level of 200 ng/ml BZO, the
sensitivity level set by the National Institute on Drug Abuse and Departments of
Health and Human Services. Note: Where indicated, any positive test should be
confirmed using quantitative methods by a qualified testing laboratory.
SUMMARY AND EXPLANATION OF THE TEST
Benzodiazepines can be insidious drugs of abuse because they are a frequently prescribed prescription drug. They represent a broad class of central nervous system depressants which have anxiolytic, hypnotic, anticonvulsant and muscle relaxant effects. Chronic abuse can result in addiction and retardive dyskinnesia. Benzodiazepines are used therapeutically to produce sedation, induce sleep, relieve anxiety and muscle spasms and to prevent seizures. In general, benzodiazepines act as hypnotics in high doses, as anxiolytics in moderate doses and as sedatives in low doses. Like the barbiturates, benzodiazepines differ from one another in how fast they take effect and how long the effects last. Shorter acting benzodiazepines, used to manage insomnia, include estazolam (ProSom), flurazepam (Dalmane), quazepam (Doral), temazepam (Restoril) and triazolam (Halcyon). Benzodiazepines with longer durations of action include alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), halazepam (Paxipam), lorazepam (Ativan), oxazepam (Serax) and prazepam (Centrax). Abuse of Benzodiazepines occurs primarily because of the "high" which replicates alcohol intoxication. Approximately 50 percent of people entering treatment for narcotic or cocaine addiction also report abusing benzodiazepines. For comprehensive information on drug testing including typical half-life or drug detection periods see the Drug Testing FAQ.
The QuickScreen™ One-Step Rapid Benzodiazepines Test utilizes a unique combination of monoclonal antibodies to
selectively identify Benzodiazepines and its major metabolites in urine with a high degree of
sensitivity. The test kit is a rapid, visually read screening method that does not require
special instrumentation or training.
The QuickScreen™ One-Step Rapid Benzodiazepines Test technology incorporates a chromatographic absorbent device in which the drug or drug metabolites in the sample compete with a Benzodiazepines derivative immobilized on a porous membrane for limited antibody sites. This is the preferred scientific method for qualitative assay. In the assay procedure, urine mixes with labeled antibody-dye conjugate and migrates through test device. When Benzodiazepines levels are below 200 ng/ml (the detection cutoff sensitivity of the test) unbound antibody-dye conjugate binds to immobilized antigen conjugate in the Test Zone ("T"), producing a pink-rose colored band that indicates a negative result. Conversely, when Benzodiazepines levels are above the detection limit of 200 ng/ml, antibody-dye conjugate binds to the free drug, forming an antigen-antibody-dye complex. The complex competes with immobilized antigen conjugate in the Test Zone, preventing the development of a pink-rose colored band. Regardless of the test result, a color band is produced in the Control Zone ("C") by a non-specific sandwich dye conjugate reaction. This band serves as a built-in quality control by demonstrating antibody recognition, verifying that the reagents are chemically active, and confirming that the test was performed correctly.
Test Device and Dropper Pipette individually sealed in foil pouch with complete instructions.
INTERPRETATION OF TEST RESULTS:
(1) pink-rose band appears in the control zone and no band appears in the test zone.
A positive result indicates the Benzodiazepines level is
200 ng/ml or higher in the test urine
The QuickScreen™ One-Step Rapid Benzodiazepines test is now available to professionals and individuals concerned with Benzodiazepines abuse. The test is one-step, fast, self-contained, individually packaged and can be performed any time the targeted drug use or abuse is suspected. The tests come in order units of five (5) individual tests at a cost per single diagnosis/screen of $4.00 for the minimum order unit. For testing situations where sample adulteration is suspect, a Rapid Urine Adulteration test is available.